Most of the riverside commercial activities are at the head of the estuary at Gweek, once a trading port serving Helston and the surrounding area. A commercial drilling rig company and a thriving boat yard carry on the maritime tradition even though access is only possible at high tide. The National Seal Sanctuary is a popular tourist attraction, operating as a home and hospital for seals and other marine animals rescued from the surrounding seas.
Gweek Quay is a traditional Cornish boatyard serving both leisure boaters and the local fishing community. The owners' interest in and knowledge of classic boats has seen the yard develop a reputation for classic yacht restoration and repairs of traditional and classic craft, as well as modern vessels.