Most of the riverside commercial activities are at the head of the estuary at Gweek, once a trading port serving Helston and the surrounding area. A commercial drilling rig company and a thriving boat yard carry on the maritime tradition even though access is only possible at high tide. The National Seal Sanctuary is a popular tourist attraction, operating as a home and hospital for seals and other marine animals rescued from the surrounding seas.
Gweek Quay is a traditional Cornish boatyard serving both leisure boaters and the local fishing community. The yard has facilities for classic yacht restoration and repairs of traditional and classic craft, as well as modern vessels.